Ketamine & Spravato

Our team and partners are available to provide detailed information about Spravato and ketamine and how they integrate into a personalized residential treatment plan, ensuring you have the support you need on your journey to lasting wellness and recovery.

Recover in Peace

Ketamine & Spravato at Amend Malibu

Get fast-acting relief from treatment-resistant depression symptoms with ketamine-assisted therapy or Spravato (an FDA-approved esketamine nasal spray), to make more space for deep therapy work during your residential treatment at Amend in Malibu. These innovative psychedelic therapies stand at the forefront of our efforts to offer you add-on adjunctive therapies to help treat the complex challenges of Treatment-Resistant Depression (TRD) and Major Depressive Disorder (MDD) with suicidal thoughts or ideation.

We ensure you have the support you need on your journey to lasting wellness and recovery.

Our Treatment

Relieve Depression Symptoms with Spravato in Malibu

Spravato nasal spray capitalizes on the unique properties of esketamine, presenting a groundbreaking approach to brain chemistry modulation, offering a glimmer of hope for those whose paths to recovery have been hindered by traditional therapies. This innovative treatment distinguishes itself through its mechanism of action, directly targeting NMDA receptors in the brain. This pathway is distinct from those affected by conventional antidepressants, enabling Spravato to provide rapid antidepressant effects and a noteworthy reduction in suicidal thoughts, serving as a crucial lifeline for clients in dire need.

In 2019, the FDA acknowledged the potential of Spravato to address the significant treatment gap in mental health care, approving its use for adults with treatment-resistant depression and for depressive symptoms in adults with major depressive disorder who have acute suicidal ideation or behavior.

The efficacy of Spravato in swiftly mitigating symptoms of severe depression has been substantiated through rigorous clinical trials and studies. Some clients have observed improvements in their condition as early as 24 hours after treatment, offering a significant advantage over traditional antidepressants and marking Spravato as a critical advancement in the fight against severe depression and suicidality.

What we Offer

What To Expect During a Spravato or Ketamine Treatment Session in Malibu

For each Spravato or ketamine session, Amend clients work with licensed, trained medical professionals to receive best-in-class treatment in a safe setting. Clients can anticipate a structured and supportive environment tailored to maximize both comfort and treatment efficacy. Upon arrival, clients are settled in a quiet, comfortable space designed to foster a calm state of mind. Ketamine is dosed and administered by a licensed medical provider and may be given IM or IV. On the other hand, esketamine nasal spray is self-administered under the guidance of an experienced healthcare provider, ensuring the correct dosage and technique.

Following administration, clients sit back and relax under observation for at least two hours to monitor for potential side effects, such as dizziness, nausea, or elevated blood pressure, and to ensure their safety. This period also allows healthcare providers to assess the immediate effects of the treatment on the client’s symptoms. Clients are encouraged to relax, journal, doodle, or engage in quiet activities throughout the session.

The entire Spravato or ketamine process is designed to be as smooth and reassuring as possible, providing a safe space for individuals to receive their treatment with the utmost care and professional oversight. Following the session, the Amend team transports each client back to Amend’s residential care for integration back into treatment and their typical therapeutic schedules.

What we Offer

Tailored Spravato or Ketamine Treatment Experience

Spravato treatment at Amend emphasizes individualized care, safety, and the overall well-being of our clients:

Supervised Administration: Spravato and ketamine are administered in a controlled setting under the supervision of healthcare professionals, ensuring client safety and monitoring for any adverse effects during and after treatment.
Comprehensive Care Strategy: Treatment with Spravato or ketamine is part of a broader therapeutic strategy that may include oral medication and integrative psychotherapy, providing a holistic approach to managing severe depression and suicidal ideation.
Individualized Treatment Plans: Dosage and treatment schedules are customized based on each client’s unique needs and response to treatment, ensuring the most effective and compassionate care.

We offer this innovative solution as part of a comprehensive plan tailored to your journey toward mental wellness.

What we Offer

The Science on Spravato for Depression

The introduction of Spravato into clinical practice for mental health treatment is bolstered by a solid foundation of scientific research and clinical trials. Spravato’s impact extends beyond the rapid alleviation of depressive symptoms, contributing to lasting improvements in mental health:

Sustained Symptom Management: Studies indicate that the benefits of Spravato can extend for several weeks post-treatment, providing a stable foundation for recovery and rehabilitation from depression (Daly et al., 2019).
Quality of Life Enhancements: Clients treated with Spravato have reported significant improvements in their overall quality of life, daily functioning, and a reduction in suicidality, underscoring the profound effect of this treatment on aspects beyond mere symptom relief (Fu et al., 2020).
Renewed Hope: For individuals who have struggled with treatment resistant depression and medication-resistant depression, Spravato offers a new avenue for hope, potentially transforming the landscape of mental health treatment for those who felt their options were exhausted.
Demonstrated Efficacy in Treatment-Resistant Depression: Research by Daly et al. (2019) highlighted the significant reductions in depressive symptoms among TRD clients treated with Spravato compared to a placebo, showcasing its potential as a critical tool in the treatment arsenal against severe depression.
Rapid Reduction of Suicidal Ideation: Canuso et al. (2018) found that Spravato rapidly reduced suicidal thoughts in clients with Major Depressive Disorder, providing essential evidence of its life-saving potential with the alleviation of suicidal ideation (SI).

Experience Our Expert Care

Navigating Spravato’s Side Effects and Treatment with Care

While Spravato is a powerful tool in treating severe depression, it does come with potential side effects and is not appropriate for everyone. Potential side effects include dissociation, dizziness, nausea, sedation, respiratory depression, and increased blood pressure. Spravato can increase the risk of suicidal thoughts and actions in some people. It also has the potential for misuse and abuse. For complete information on potential side effects, please visit spravato.com. Our Amend Treatment team and partners are committed to providing the highest level of care, guiding clients through their treatment journey with empathy, expertise, and support.

Learn the Research

The Science on Ketamine for Depression and Mental Health

Ketamine is gaining attention as a significant advancement in the treatment of depression, particularly for those conditions that are resistant to other treatments. This understanding is based on solid research and clinical trials:

Prolonged Relief from Depression

A large-scale study published in the New England Journal of Medicine compared the effectiveness of ketamine to electroconvulsive therapy (ECT) in treating severe, non-psychotic, treatment-resistant depression. This study found that 55% of participants receiving ketamine showed a sustained improvement in depressive symptoms, suggesting that ketamine can offer extended relief in severe cases (Anand, 2023).

Enhanced Well-being and Functionality

The rapid antidepressant effects of ketamine are not only quick but also significant, providing improved quality of life and functionality. This outcome highlights its potential as a transformative treatment for severe depression (ScienceDaily, 2023).

Hope for the Hard-to-Treat

For individuals with depression that have not responded to other medications, ketamine offers new hope. The findings indicate that ketamine could be a viable alternative to more invasive treatments like ECT, especially given its ability to improve symptoms with fewer side effects related to cognitive functions such as memory (Anand, 2023).

Effective in Severe Cases

The research underscores ketamine’s efficacy in severe and treatment-resistant cases of depression, providing a potent alternative where traditional treatments may fail (ScienceDaily, 2023).

Quick Impact on Suicidal Ideation

Studies have also shown ketamine’s rapid effects on reducing suicidal thoughts, which is critical for acute crisis intervention in severe depression cases (Anand, 2023).

Trust the Experts

Navigating Ketamine’s Side Effects and Treatment with Care

Like Spravato, ketamine treatment does come with potential side effects, such as dissociation, sedation, and elevated blood pressure (Anand, 2023). For more information and complete clarity on potential side effects, please discuss with your doctor and Amend treatment team. They’ll help you decide if ketamine is right for you.

Spravato treatment at Amend emphasizes individualized care, safety, and the overall well-being of our clients

Start Today

Begin Your Recovery with Spravato or Ketamine During Residential Treatment in Malibu

Incorporating Spravato and ketamine into our holistic treatment philosophy, we at Amend Treatment are dedicated to offering this innovative solution as part of a comprehensive plan tailored to your journey toward mental wellness.

Embark on a New Path

If you’re ready to explore how Spravato or ketamine can be a part of your recovery, reach out for a confidential consultation today. Our compassionate team is here to support you every step of the way. Take your next step with a free, confidential consultation over the phone at (866) 875-3411, or submit your insurance information for a free benefits verification. Our experienced team looks forward to hearing your story and working with you to decide if we are the right fit.

Further Information and Support

Making informed decisions about your mental health treatment is vital. Our team and partners are available to provide detailed information about Spravato and ketamine and how they integrate into a personalized residential treatment plan, ensuring you have the support you need on your journey to lasting wellness and recovery.

Content References

Anand, A. et al. (2023). Large-scale study on ketamine’s efficacy in treatment-resistant depression compared with ECT. New England Journal of Medicine.
Canuso, C. M., Singh, J. B., Fedgchin, M., Alphs, L., Lane, R., Lim, P., … & Hough, D. (2018). Efficacy and safety of intranasal esketamine for the rapid reduction of symptoms of depression and suicidality in patients at imminent risk for suicide: results of a double-blind, randomized, placebo-controlled study. American Journal of Psychiatry, 175(7), 620-630.
Daly, E. J., Singh, J. B., Fedgchin, M., Cooper, K., Lim, P., Shelton, R. C., … & Drevets, W. C. (2019). Efficacy and safety of esketamine nasal spray plus an oral antidepressant in patients with treatment-resistant depression: a randomized clinical trial. JAMA Psychiatry, 76(2), 139-148.
Fedgchin, M., Trivedi, M., Daly, E. J., Melkote, R., Lane, R., Lim, P., … & Van Nueten, L. (2019). Efficacy and Safety of Fixed-Dose Esketamine Nasal Spray Combined With a New Oral Antidepressant in Treatment-Resistant Depression: Results of a Randomized, Double-Blind, Active-Controlled Study (TRANSFORM-1). International Journal of Neuropsychopharmacology, 22(10), 616-630.
Fu, D. J., Ionescu, D. F., Li, X., Lane, R., Lim, P., Sanacora, G., … & Drevets, W. C. (2020). Esketamine Nasal Spray for Rapid Reduction of Major Depressive Disorder Symptoms in Patients Who Have Active Suicidal Ideation With Intent: Double-Blind, Randomized Study (ASPIRE I). J Clin Psychiatry, 81(3), 19m13191.
FDA (2019). FDA approves new nasal spray medication for treatment-resistant depression; available only at a certified doctor’s office or clinic. U.S. Food and Drug Administration.
University of New South Wales. (2023). Ketamine effective for treatment-resistant depression. ScienceDaily.

Insurance Options

Understand Your Coverage – Fast & Confidential

Amend is redefining what mental health treatment looks like with a team of highly experienced and licensed healthcare professionals focused solely on you and your recovery. While insurance may only partially cover your stay at Amend, our team is ready to discuss available private pay options with you. Please note that Amend does not accept Medicare, Medicaid, Kaiser, HMO, or EPO plans. We only accept plans with out of network benefits (PPO).

Helping Clients Everyday

Stories of Success and Recovery

Our client testimonials offer a window into the real-life impact of treatment at Amend Malibu. Our clients share what it’s like to engage in the process, build trust with our providers, and see the potential for meaningful change.

Anna H.

A small community in Malibu, this is a group of individuals dedicated to making a difference in patient lives. Each touch point from admissions to specialists, the clinicians, the kitchen, to the clinical assistants you are handled with love and support. Managing two decades of treatment resistant depression and working through burnout from an intense performance based career, I needed a place to get grounded as well as inundate myself with professionals who could help.

Marlon R.

Absolutely stunning properties in a prime yet private location. The treatment environment matters and I was highly impressed. The care environment was clean and organized. The staff were friendly and dressed professionally. The chefs were cordial and accommodating. There was easy access to many tranquil activities as well as fitness activities. The frequency of the individual therapy session was top notch up to 4 times a week plus weekly virtual visits with psychiatry and psychological testing. This type of clinical focus is rare. This is a great example of premium treatment.

Goli S.

I helped facilitate care for a dear friend at Amend. I was skeptical about any mental health program, but was blown away by the level of care at the facility. The whole team went above and beyond to ensure comfort and the best level of care in a way that is indescribable. I really do not have anything negative to say. Every aspect of the program and facility is 100/10. I would highly recommend Amend to anyone struggling with mental health.

Care You can trust

Affiliations & Accreditations

Amend Treatment maintains measurable outcome results in the top 5–15% among premier residential treatment centers, nationwide, in 2025.

Start Your Healing Journey

You Don’t Have to Navigate This Alone

Recovery begins the moment you are truly seen and supported. Whether you are managing complex trauma, depression, or co-occurring disorders, we provide the expert clinical guidance and serene environment necessary to reclaim your future.

Your journey toward healing starts with a confidential conversation. Please fill out the form, and our admissions team will reach out to discuss how we can support your recovery.

Ketamine & Spravato